Clinical Informatician (Senior Cancer RWD Analyst)

Guy's and St Thomas' NHS Foundation Trust

Job summary

This is an exciting opportunity to take a key role in the AI Centre for Value-Based Healthcare, working with the Guy’s Cancer Real-World Evidence (RWE) team.

The Clinical Informatician (Senior Cancer RWD Analyst) bridges RWD and RWE, with a focus on thoracic cancers. The post-holder will curate and develop regulatory-grade, deep cancer data assets, ensuring that outputs are clinically meaningful, aligned with research and commercial needs, and grounded in real-world cancer care delivery.

Essential Criteria:

  • Clinical background with understanding of oncology domain
  • Expertise in clinical data and informatics, including source systems and clinical and oncology-specific vocabularies
  • Expertise in SQL and Python (+/- R) to engineer and analyse datasets, validate cohort definitions, and generate insights and visualisations
  • Understanding of cancer clinical research, pharma study / clinical trials, and regulatory requirements for RWD/RWE in oncology
  • Excellent stakeholder engagement skills, with the ability to translate between engineering, clinical, and scientific audiences
  • Excellent project management skills

Desirable Criteria:

  • Experience overseeing clinical validation of NLP-derived features extracted from unstructured medical records
  • Track record of high-impact research output and/or commercial partnership delivery in RWE
  • Experience building or working with solutions on cloud data platforms (e.g. Snowflake)

Main duties of the job

Main duties of the job

  • Curate and develop regulatory-grade, deep cancer data assets, focused initially on thoracic malignancies, by defining and validating cohort logic, clinical variables, and derived endpoints.
  • Oversee clinical validation of features extracted from unstructured records (clinic letters, radiology, pathology, MDT) and feed back into pipeline improvement.
  • Act as the clinical-informatics bridge between AI Centre data engineers and the Guy’s Cancer RWE team, translating between clinical, scientific, and engineering audiences.
  • Take the analytical lead on highly complex cancer data, devising methods, setting data-quality KPIs, and making evidence-based recommendations to stakeholders.
  • Engage and influence clinical, academic, and commercial partners, and contribute to research outputs and longer-term strategic partnerships.
  • Lead and mentor within matrixed project teams, supporting capability-building and the effective use of project resources.

Person Specification

Background

Essential

  • Clinical background with an understanding of the oncology domain
  • Understanding of cancer clinical research, pharma study / clinical trials, and regulatory requirements for RWD/RWE in oncology

Desirable

  • Experience overseeing clinical validation of NLP-derived features extracted from unstructured medical records
  • Track record of high-impact research output and/or commercial partnership delivery in RWE

Technical

Essential

  • Expertise in clinical data and informatics, including understanding of source systems and clinical and oncology-specific vocabularies
  • Expertise in SQL and Python (+/- R) sufficient to engineer and analyse datasets, validate cohort definitions, and generate insights and visualisations

Desirable

  • Experience building or working with solutions on cloud data platforms (e.g. Snowflake)

General

Essential

  • Excellent stakeholder engagement skills, with the ability to translate between engineering, clinical, and scientific audiences
  • Excellent project management skills

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

Closing Date: 21 July 2026

To apply for this job please visit apps.trac.jobs.